Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 4/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | INSR | P06213 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LYN | P07948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116598 | 0.84 | BRS3 (0.41) | BRS3CYP1A2CYP2D6CYP2C19LMNA | |
| SCHEMBL8298317 | 0.77 | BRS3 (0.48) | BRS3OPRM1ABCG2CYP19A1 | |
| Hydrochloric Acid SCHEMBL8304229 | 0.76 | BRS3 (0.47) | BRS3OPRM1ABCG2CYP19A1 | |
| SCHEMBL8115034 | 0.75 | GRIN1 (0.38) | BRS3CYP1A2CYP2C19LMNAOPRM1 | |
| SCHEMBL8120803 | 0.73 | FNTA (0.52) | KCNH2 | |
| SCHEMBL7461594 | 0.73 | BRS3 (0.48) | BRS3EP300 | |
| SCHEMBL7919393 | 0.72 | BRS3 (0.62) | BRS3CYP19A1GRIN1GRIN2BEP300 | |
| Hydrochloric Acid SCHEMBL8004159 | 0.72 | BRS3 (0.48) | BRS3EP300 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.71 | BRS3 (0.61) | BRS3CYP19A1GRIN1GRIN2BEP300 | |
| SCHEMBL7924356 | 0.70 | BRS3 (0.72) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019391-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999018096-A1 | INHIBITORS OF PRENYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1999-04-15 | — | — | WO | disclosed |