⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2137371 | 0.85 | NPC1 (0.32) | — | |
| SCHEMBL247314 | 0.82 | KDM4E (0.31) | — | |
| SCHEMBL813302 | 0.82 | KDM4E (0.31) | — | |
| SCHEMBL2966308 | 0.77 | TYR (0.34) | — | |
| SCHEMBL7989380 | 0.76 | CNR1 (0.34) | — | |
| SCHEMBL6024656 | 0.76 | F2RL1 (0.31) | — | |
| SCHEMBL2139795 | 0.75 | — | — | |
| SCHEMBL8407990 | 0.74 | F2RL1 (0.31) | — | |
| SCHEMBL2972560 | 0.74 | LIPG (0.39) | — | |
| SCHEMBL4680152 | 0.73 | TAAR1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6133276-A | A LIGAND INHIBITOR OF A CRF/CRF-BINDING PROTEIN COMPLEX TO EFFECT INCREASED LEVELS OF CRF; 2,4-DIOXO- OR 2-THIOCARBONYL-4-OXO-5-(HYDROCARBYL(THIO)CARBONYLAMINOMETHYL)-6-HYDROXY-HEXA-HEXAHYDROPYRIMIDINES; ALZHEIMER'S, OBESITY; LOW SIDE EFFECTS | NEUROCRINE BIOSCIENCES, INC. (US) | 2000-10-17 | — | — | US | disclosed |
| US-5959109-A | A LIGAND INHIBITOR CAUSES RELASES OF CORTICOTROPIN-RELEASING FACTOR FROM THE CORTICOTROPIN/CORTICOTROPIN-BINDING PROTEIN COMPLEX, PROVIDES IMPROVEMENT IN LEARNING AND MEMORY | NEUROCRINE BIOSCIENCES, INC. (US) | 1999-09-28 | — | — | US | disclosed |