Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 8/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.45 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30344677 | 0.95 | SLC6A3 (0.42) | SLC6A3SLC6A4SLC6A2NR4A1NR4A2 | |
| SCHEMBL8747018 | 0.95 | SLC6A3 (0.42) | SLC6A3SLC6A4SLC6A2NR4A1NR4A2 | |
| SCHEMBL8112531 | 0.84 | AKR1C1 (0.52) | SLC6A3SLC6A4SLC6A2NR4A1NR4A2 | |
| SCHEMBL12020292 | 0.83 | SLC6A3 (0.46) | SLC6A3SLC6A4SLC6A2NR4A1NR4A2 | |
| SCHEMBL697151 | 0.79 | AKR1C1 (0.48) | SLC6A3SLC6A4SLC6A2NR4A1NR4A2 | |
| SCHEMBL27926942 | 0.78 | SLC6A3 (0.53) | SLC6A3SLC6A4SLC6A2HDAC4AKR1C1 | |
| SCHEMBL8104865 | 0.75 | HDAC4 (0.44) | HDAC4AKR1C1MEN1KMT2A | |
| SCHEMBL2944626 | 0.74 | SLC6A3 (0.55) | SLC6A3SLC6A4SLC6A2HDAC4MEN1 | |
| SCHEMBL25155178 | 0.74 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2MEN1MAPT | |
| SCHEMBL30344744 | 0.74 | SLC6A3 (0.50) | SLC6A3SLC6A4SLC6A2MEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124354-A | TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME | PHARMACIA & UPJOHN AB (SE) | 2000-09-26 | — | — | US | disclosed |