Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 5/20 | 0.42 |
| ▸ | SLC6A4 known ✓ | P31645 | 5/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 5/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8106535 | 1.00 | SLC6A2 (0.42) | SLC6A2SLC6A4SLC6A3HTR6HRH3 | |
| SCHEMBL8107623 | 0.79 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3HTR6IRAK4 | |
| SCHEMBL8107625 | 0.79 | SLC6A2 (0.57) | SLC6A2SLC6A4SLC6A3HTR6IRAK4 | |
| Bromide SCHEMBL8108934 | 0.73 | HRH3 (0.37) | HRH3BACE1IRAK4EGLN1 | |
| SCHEMBL5829723 | 0.67 | SLC6A2 (0.53) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL5829382 | 0.66 | SLC6A2 (0.52) | SLC6A2SLC6A4SLC6A3HTR6NOS3 | |
| SCHEMBL5829679 | 0.66 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL5829744 | 0.66 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL5829678 | 0.66 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HTR6 | |
| SCHEMBL5829742 | 0.66 | SLC6A2 (0.54) | SLC6A2SLC6A4SLC6A3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107307-A | PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0969005-A1 | Azabicyclic inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1999065492-A1 | INHIBITION OF SEROTONIN REUPTAKE | ELI LILLY AND COMPANY (US) | 1999-12-23 | — | — | WO | disclosed |