Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRS3 | P32247 | 12/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8306714 | 0.99 | BRS3 (0.48) | BRS3TSHRHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL8097357 | 0.94 | BRS3 (0.51) | BRS3TSHRHSD17B10CYP11B1CYP11B2 | |
| Hydrochloric Acid SCHEMBL8307882 | 0.93 | BRS3 (0.50) | BRS3TSHRHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL8105023 | 0.87 | BRS3 (0.52) | BRS3CYP11B1CYP11B2HRH3 | |
| Hydrochloric Acid SCHEMBL8305243 | 0.86 | BRS3 (0.51) | BRS3CYP11B1CYP11B2HRH3 | |
| SCHEMBL7927535 | 0.84 | BRS3 (0.52) | BRS3CYP11B1CYP11B2HRH3 | |
| SCHEMBL7919393 | 0.83 | BRS3 (0.62) | BRS3CYP11B1CYP11B2HRH3 | |
| Hydrochloric Acid SCHEMBL8521500 | 0.82 | BRS3 (0.61) | BRS3CYP11B1CYP11B2HRH3 | |
| SCHEMBL8107069 | 0.79 | BRS3 (0.51) | BRS3TSHRHSD17B10CYP11B1CYP11B2 | |
| SCHEMBL7924356 | 0.79 | BRS3 (0.72) | BRS3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0986302-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2000-03-22 | — | — | EP | claimed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1998054966-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | claimed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0986302-A1 | A METHOD OF TREATING CANCER | Merck & Co., Inc. (US) | 2000-03-22 | — | — | EP | disclosed |
| EP-0891333-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1998054966-A1 | A METHOD OF TREATING CANCER | MERCK & CO., INC. (US) | 1998-12-10 | — | — | WO | disclosed |
| WO-1997036875-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |