Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 6/20 | 0.70 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.70 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.70 |
| ▸ | NOS3 | P29474 | 1/20 | 0.49 |
| ▸ | NOS1 | P29475 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 7/20 | 0.45 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106666 | 1.00 | SLC6A4 (0.70) | SLC6A4SLC6A2SLC6A3NOS3NOS1 | |
| SCHEMBL2883041 | 0.76 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3NOS3NOS1 | |
| SCHEMBL2883039 | 0.76 | SLC6A2 (0.52) | SLC6A4SLC6A2SLC6A3NOS3NOS1 | |
| SCHEMBL1122235 | 0.74 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3NOS3NOS1 | |
| SCHEMBL1122233 | 0.74 | SLC6A4 (0.64) | SLC6A4SLC6A2SLC6A3NOS3NOS1 | |
| SCHEMBL1335541 | 0.72 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3HTR6 | |
| SCHEMBL5850045 | 0.71 | MAPK14 (0.60) | SLC6A4SLC6A2SLC6A3 | |
| SCHEMBL6553682 | 0.71 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3HTR6HTR1A | |
| SCHEMBL5830039 | 0.71 | SLC6A4 (0.58) | SLC6A4SLC6A2SLC6A3HTR6HTR1A | |
| SCHEMBL6497949 | 0.71 | TDO2 (0.46) | SLC6A4TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6107307-A | PSYCHOLOGICAL DISORDERS | ELI LILLY AND COMPANY (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0969005-A1 | Azabicyclic inhibitors of serotonin reuptake | ELI LILLY AND COMPANY (US) | 2000-01-05 | — | — | EP | disclosed |