Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.55 |
| ▸ | CASR | P41180 | 6/20 | 0.46 |
| ▸ | KHK | P50053 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.44 |
| ▸ | XIAP | P98170 | 1/20 | 0.44 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | DHFR | P00374 | 1/20 | 0.44 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | MLYCD | O95822 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5272828 | 0.91 | NOTUM (0.45) | NOTUMCASRKHKACACBADRB1 | |
| SCHEMBL8108584 | 0.88 | NOTUM (0.44) | NOTUMCASRKHKACACBADRB1 | |
| SCHEMBL1471079 | 0.85 | MCHR1 (0.44) | CASRKHKADRB1XIAPBIRC2 | |
| SCHEMBL1005159 | 0.85 | MCHR1 (0.44) | CASRKHKADRB1XIAPBIRC2 | |
| SCHEMBL1471081 | 0.85 | MCHR1 (0.44) | CASRKHKADRB1XIAPBIRC2 | |
| SCHEMBL1472870 | 0.85 | NOTUM (0.52) | NOTUMCASRACACBPIM1DHFR | |
| SCHEMBL1472865 | 0.85 | NOTUM (0.52) | NOTUMCASRACACBPIM1DHFR | |
| Hydrochloric Acid SCHEMBL2244493 | 0.83 | MCHR1 (0.43) | CASRKHKADRB1XIAPBIRC2 | |
| SCHEMBL2873025 | 0.83 | ADRB1 (0.65) | KHKADRB1MAPT | |
| SCHEMBL2873027 | 0.83 | ADRB1 (0.65) | KHKADRB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |