Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 12/20 | 0.75 |
| ▸ | LTA4H | P09960 | 5/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7999188 | 0.97 | HRH3 (0.75) | HRH3LTA4HHRH1KDM4EALDH1A1 | |
| SCHEMBL11258501 | 0.88 | LTA4H (0.83) | HRH3LTA4HKDM4EALDH1A1KCNH2 | |
| SCHEMBL8002632 | 0.87 | HRH3 (0.73) | HRH3LTA4HHRH1 | |
| SCHEMBL8114961 | 0.87 | HRH3 (0.73) | HRH3LTA4HALDH1A1 | |
| SCHEMBL7995012 | 0.87 | HRH3 (0.83) | HRH3LTA4HKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL19043356 | 0.87 | HRH3 (0.76) | HRH3LTA4H | |
| SCHEMBL19043080 | 0.86 | HRH3 (0.77) | HRH3LTA4H | |
| SCHEMBL492205 | 0.85 | HRH3 (0.84) | HRH3LTA4HHRH1KDM4EALDH1A1 | |
| SCHEMBL7397639 | 0.85 | LTA4H (0.78) | HRH3LTA4HHRH1KDM4EALDH1A1 | |
| SCHEMBL13493035 | 0.85 | KDM4E (0.74) | HRH3LTA4HKDM4EALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2320886-B1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORP (US) | 2017-06-28 | — | — | EP | disclosed |
| WO-2010014554-A1 | GLUCOSYLCERAMIDE SYNTHASE INHIBITION FOR THE TREATMENT OF COLLAPSING GLOMERULOPATHY AND OTHER GLOMERULAR DISEASE | GENZYME CORPORATION (US) | 2010-02-04 | — | — | WO | disclosed |
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |