SCHEMBL8107779

SCHEMBL8107779

NCCc1cccc(F)c1.NCc1ccccc1N

nearest known ligand 0.69

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
TAAR1 Q96RJ0 11/20 0.69
MAOB P27338 6/20 0.49
DRD2 P14416 1/20 0.42
DRD1 P21728 1/20 0.42
HTR2C P28335 1/20 0.41
HTR6 P50406 1/20 0.41
CYP2A6 P11509 1/20 0.41
HTR2A P28223 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
IDO1 P14902 1/20 0.41
AGXT P21549 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bipenamol SCHEMBL8426708 0.85 TAAR1 (0.50) TAAR1MAOBDRD2DRD1HTR2C
SCHEMBL4221500 0.83 TAAR1 (0.56) TAAR1MAOBDRD2IDO1AGXT
SCHEMBL29429505 0.83 TAAR1 (1.00) TAAR1MAOBDRD2DRD1HTR2C
SCHEMBL146545 0.83 TAAR1 (1.00) TAAR1MAOBDRD2DRD1HTR2C
Hydrochloric Acid SCHEMBL5728333 0.81 TAAR1 (0.96) TAAR1MAOBDRD2DRD1CYP2A6
Bromide SCHEMBL30599495 0.81 TAAR1 (0.96) TAAR1MAOBDRD2DRD1CYP2A6
Iodide SCHEMBL30472769 0.81 TAAR1 (0.96) TAAR1MAOBDRD2DRD1CYP2A6
Iodide SCHEMBL29040442 0.81 TAAR1 (0.96) TAAR1MAOBDRD2DRD1CYP2A6
Bromide SCHEMBL28591635 0.81 TAAR1 (0.96) TAAR1MAOBDRD2DRD1CYP2A6
SCHEMBL27969366 0.80 TAAR1 (0.61) TAAR1MAOBDRD2IDO1AGXT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0973936-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 2000-01-26 EP disclosed
WO-1998046786-A1 COMBINATORIAL LIBRARIES OF PEPTIDOMIMETIC AMINOTHIOETHER ACIDS ELI LILLY AND COMPANY (US) 1998-10-22 WO disclosed