Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ILK | Q13418 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL95067 | 0.84 | NPC1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL31276816 | 0.84 | NPC1 (0.55) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL95066 | 0.82 | SMN1; SMN2 (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL8244075 | 0.79 | PDE10A (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL14806544 | 0.79 | PDE10A (0.49) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL31487019 | 0.79 | PDE10A (0.59) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL95592 | 0.78 | PDE10A (0.58) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL21536795 | 0.78 | POLB (0.52) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL30747343 | 0.78 | SMN1; SMN2 (0.51) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 | |
| SCHEMBL2706157 | 0.78 | TDP1 (0.77) | SMN1; SMN2ALDH1A1NPC1RAB9AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008139941-A1 | SUBSTITUTED IMIDAZOLE COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2008-11-20 | — | — | WO | disclosed |