Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8104215 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8102553 | 0.77 | NPC1 (0.54) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8102557 | 0.77 | NPC1 (0.54) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8094757 | 0.77 | HTT (0.51) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8094756 | 0.77 | HTT (0.51) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8102648 | 0.77 | HTT (0.51) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8102549 | 0.77 | NPC1 (0.54) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8102580 | 0.76 | KMT2A (0.40) | KMT2A | |
| SCHEMBL8104181 | 0.68 | HTT (0.50) | SMN1; SMN2POLBNPC1RAB9AHTT | |
| SCHEMBL8104235 | 0.68 | HTT (0.50) | SMN1; SMN2POLBNPC1RAB9AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |