Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108415 | 0.70 | KMT2A (0.39) | KMT2AATM | |
| SCHEMBL8108507 | 0.69 | KMT2A (0.38) | KMT2AATM | |
| SCHEMBL8104112 | 0.66 | KMT2A (0.35) | KMT2AALDH1A1 | |
| SCHEMBL8094793 | 0.66 | L3MBTL1 (0.37) | KMT2AALDH1A1 | |
| SCHEMBL18106803 | 0.61 | L3MBTL1 (0.43) | KMT2AALDH1A1 | |
| SCHEMBL6162476 | 0.60 | KMT2A (0.39) | KMT2AALDH1A1 | |
| SCHEMBL22728348 | 0.59 | KMT2A (0.50) | KMT2AATMALDH1A1 | |
| SCHEMBL4141480 | 0.58 | KMT2A (0.44) | KMT2AATMALDH1A1 | |
| SCHEMBL3553474 | 0.57 | KMT2A (0.47) | KMT2AATMALDH1A1 | |
| SCHEMBL4756856 | 0.57 | KMT2A (0.56) | KMT2AATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | disclosed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | disclosed |