Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13109889 | 0.80 | SLC6A4 (0.35) | AVPR1ASIGMAR1 | |
| SCHEMBL14477412 | 0.76 | PDK2 (0.39) | PDK2AVPR1A | |
| SCHEMBL16661512 | 0.76 | PDK2 (0.40) | PDK2 | |
| SCHEMBL16661510 | 0.73 | PDK2 (0.34) | PDK2 | |
| SCHEMBL9420013 | 0.72 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL24435609 | 0.72 | HTR2A (0.38) | PDK2 | |
| SCHEMBL6401593 | 0.71 | PDK2 (0.42) | PDK2 | |
| SCHEMBL1875186 | 0.69 | ABCG2 (0.41) | PDK2 | |
| SCHEMBL2619379 | 0.68 | HTR2A (0.41) | SIGMAR1 | |
| SCHEMBL25129913 | 0.68 | SIGMAR1 (0.40) | AVPR1ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032571-A1 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 2000-09-06 | — | — | EP | claimed |
| WO-1999025714-A1 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-05-27 | — | — | WO | claimed |
| EP-1032571-A1 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER INC. (US) | 2000-09-06 | — | — | EP | disclosed |
| WO-1999025714-A1 | PIPERIDINYLAMINOMETHYL TRIFLUOROMETHYL CYCLIC ETHER COMPOUNDS AS SUBSTANCE P ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-05-27 | — | — | WO | disclosed |