Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | GMNN | O75496 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | THPO | P40225 | 1/20 | 0.52 |
| ▸ | MTOR | P42345 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | CETP | P11597 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | UBE2N | P61088 | 1/20 | 0.52 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.46 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.46 |
| ▸ | GPR84 | Q9NQS5 | 6/20 | 0.45 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16078651 | 1.00 | SPHK1 (0.61) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL16078645 | 1.00 | SPHK1 (0.61) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL16078685 | 1.00 | SPHK1 (0.61) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL16078693 | 1.00 | SPHK1 (0.61) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL16078657 | 1.00 | SPHK1 (0.61) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL3148122 | 0.91 | SPHK1 (0.56) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL1767673 | 0.90 | SPHK1 (0.48) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL3344513 | 0.87 | SPHK1 (0.62) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL7756046 | 0.87 | SPHK1 (0.62) | SPHK1CYP2D6LMNAGMNNPOLB | |
| SCHEMBL10607850 | 0.87 | SPHK1 (0.62) | SPHK1CYP2D6LMNAGMNNPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045856-A1 | NOVEL AROMATIC AMIDES, PREPARATION METHOD AND APPLICATION AS MEDICINES | HOECHST MARION ROUSSEL (FR) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035155-A1 | NOVEL AROMATIC AMIDES, PREPARATION METHOD AND APPLICATION AS MEDICINES | HOECHST MARION ROUSSEL (FR) | 1999-07-15 | — | — | WO | disclosed |