Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 6/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | CTH | P32929 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6269704 | 0.78 | — | — | |
| SCHEMBL7469761 | 0.76 | SLC29A1 (0.37) | SLC29A1CRHR1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL4723984 | 0.76 | MAPT (0.41) | CRHR1SMN1; SMN2NPC1RAB9AMEN1 | |
| SCHEMBL2115019 | 0.75 | SLC29A1 (0.53) | SLC29A1CRHR1SMN1; SMN2DYRK1ACTH | |
| SCHEMBL11135158 | 0.71 | SLC29A1 (0.39) | SLC29A1SMN1; SMN2HSD17B10USP2ALDH1A1 | |
| SCHEMBL5824071 | 0.71 | DNM1 (0.39) | SLC29A1CRHR1SMN1; SMN2USP2CYP1A2 | |
| SCHEMBL4723956 | 0.70 | TDP1 (0.37) | SMN1; SMN2USP2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL14029791 | 0.69 | DYRK1A (0.44) | SLC29A1CRHR1SMN1; SMN2DYRK1ACDC7 | |
| SCHEMBL4765553 | 0.69 | SMN1; SMN2 (0.39) | CRHR1SMN1; SMN2NPC1RAB9AMAPK1 | |
| SCHEMBL29135407 | 0.69 | DNM1 (0.43) | SLC29A1CRHR1SMN1; SMN2USP2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0920318-A4 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | DU PONT PHARM CO (US) | 2000-03-15 | — | — | EP | claimed |
| EP-0920318-A1 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | Du Pont Pharmaceuticals Company (US) | 1999-06-09 | — | — | EP | claimed |
| WO-1997035580-A1 | ARYLOXY- AND ARYLTHIOSUBSTITUTED PYRIMIDINES AND TRIAZINES AND DERIVATIVES THEREOF | DU PONT PHARMACEUTICALS COMPANY (US) | 1997-10-02 | — | — | WO | claimed |