SCHEMBL8108959

SCHEMBL8108959

CCCc1cccc(C(C)(C)C)c1-n1cc(CCC)n(Cc2ccc(-c3cnccc3-c3nnn[nH]3)cc2)c1=O

nearest known ligand 0.39

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 7/20 0.39
AGTR2 P50052 7/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8121169 0.98 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL8110986 0.97 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL8106627 0.96 AGTR1 (0.44) AGTR1AGTR2
SCHEMBL8117905 0.95 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL8109523 0.95 AGTR1 (0.42) AGTR1AGTR2
SCHEMBL8124679 0.94 AGTR1 (0.44) AGTR1AGTR2
SCHEMBL8106832 0.93 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL8109040 0.93 AGTR1 (0.48) AGTR1AGTR2
SCHEMBL8109622 0.92 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL8122335 0.92 AGTR1 (0.43) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0664802-B1 N-ARYLHETEROARYLALKYL 1-PHENYL-IMIDAZOL-2-ONE COMPOUNDS FOR TREATMENT OF CIRCULATORY DISORDERS SEARLE & CO (US) 2000-03-15 EP disclosed