Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 1/20 | 0.35 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | ITGAL | P20701 | 1/20 | 0.35 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | CRHBP | P24387 | 2/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10622763 | 0.84 | DRD2 (0.36) | — | |
| SCHEMBL28297416 | 0.75 | ITGB2 (0.41) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL12609018 | 0.75 | MAP3K14 (0.42) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL12609033 | 0.75 | MAP3K14 (0.42) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL802264 | 0.75 | MAP3K14 (0.42) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL21423461 | 0.72 | ITGB2 (0.39) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL29332749 | 0.72 | MAP3K14 (0.40) | ITGB2ICAM1ITGALSSTR4LMNA | |
| SCHEMBL9053970 | 0.70 | IDO1 (0.46) | — | |
| SCHEMBL6652443 | 0.70 | SSTR4 (0.41) | ITGB2ICAM1ITGALSSTR4SMN1; SMN2 | |
| SCHEMBL11665711 | 0.69 | IDO1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779288-B1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AG (DE) | 2000-03-29 | — | — | EP | disclosed |
| US-5811448-A | PHARMACEUTICALS USEFUL FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-09-22 | — | — | US | disclosed |
| EP-0779288-A1 | Substituted chromanylsulfonyl(thio)ureas, process for their preparation, their use in pharmaceutical compositions and preparations containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-18 | — | — | EP | disclosed |