Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.55 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.53 |
| ▸ | PTAFR | P25105 | 7/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.44 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8108762 | 0.99 | EPHX2 (0.56) | EPHX2PDE3BPTAFRMAPTKMT2A | |
| SCHEMBL8100659 | 0.85 | LMNA (0.55) | PDE3BMAPTKMT2AMEN1ALDH1A1 | |
| SCHEMBL10473805 | 0.78 | PDE3B (0.68) | PDE3BMAPTKMT2ARAB9AMEN1 | |
| SCHEMBL8688373 | 0.77 | EPHX2 (0.57) | EPHX2PTAFRMAPTKMT2ARAB9A | |
| SCHEMBL8687905 | 0.77 | EPHX2 (0.57) | EPHX2PTAFRMAPTKMT2ARAB9A | |
| SCHEMBL5553310 | 0.76 | EPHX2 (0.92) | EPHX2PTAFRMAPTKMT2ARAB9A | |
| SCHEMBL8912740 | 0.76 | PDE3B (0.46) | EPHX2PDE3BMAPTKMT2ARAB9A | |
| SCHEMBL8110044 | 0.75 | EPHX2 (0.58) | EPHX2PTAFRMAPTKMT2ARAB9A | |
| SCHEMBL8687678 | 0.75 | EPHX2 (0.58) | EPHX2PTAFRMAPTKMT2ARAB9A | |
| SCHEMBL8116045 | 0.75 | KMT2A (0.55) | EPHX2PDE3BMAPTKMT2ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751132-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 2000-08-30 | — | — | EP | disclosed |
| EP-0751132-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1997-01-02 | — | — | EP | disclosed |