Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGAM | O43451 | 1/20 | 0.68 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.59 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 5/20 | 0.58 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.58 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | MAP4K5 | Q9Y4K4 | 1/20 | 0.58 |
| ▸ | CA12 | O43570 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CA9 | Q16790 | 1/20 | 0.57 |
| ▸ | FASN | P49327 | 1/20 | 0.55 |
| ▸ | PTGES | O14684 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.53 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.53 |
| ▸ | MMP1 | P03956 | 1/20 | 0.52 |
| ▸ | MMP9 | P14780 | 1/20 | 0.52 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613435 | 0.86 | CA12 (0.60) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL12797767 | 0.84 | NPC1 (0.64) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL24621829 | 0.84 | PDGFRB (0.72) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL29375510 | 0.84 | PDGFRB (0.72) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL26829682 | 0.84 | PDGFRB (0.72) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL4130703 | 0.84 | PDGFRB (0.56) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL4123055 | 0.84 | MGAM (0.58) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL12580411 | 0.83 | PDGFRB (0.66) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL12580402 | 0.83 | PDGFRB (0.66) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 | |
| SCHEMBL12580362 | 0.83 | PDGFRB (0.66) | MGAMPDGFRBPDGFRAMAP4K4CSNK1G2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1260781-A | Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity | SMITHKLINE BEECHAM PLC (GB) | 2000-07-19 | — | — | CN | disclosed |
| EP-0975593-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998050358-A1 | INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY | SMITHKLINE BEECHAM PLC (GB) | 1998-11-12 | — | — | WO | disclosed |