⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079693 | 1.00 | — | — | |
| SCHEMBL191431 | 1.00 | — | — | |
| SCHEMBL9792876 | 1.00 | — | — | |
| SCHEMBL8109466 | 1.00 | — | — | |
| SCHEMBL11007855 | 0.83 | GBA2 (0.30) | — | |
| SCHEMBL6857765 | 0.83 | GBA2 (0.30) | — | |
| SCHEMBL19174844 | 0.80 | — | — | |
| SCHEMBL19136724 | 0.80 | — | — | |
| SCHEMBL15024141 | 0.77 | — | — | |
| SCHEMBL1973814 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5973161-A | CATALYTIC CYCLIZING CORRESPONDING LINEAR COMPOUND IN A ORGANIC SOLVENT AT A TEMPERATURE BETWEEN ABOUT-78 DEGREES C AND ABOUT 150 DEGREES C | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-10-26 | — | — | US | claimed |
| US-20180290983-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2018-10-11 | — | — | US | disclosed |
| EP-3323414-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2018-05-23 | — | — | EP | disclosed |
| US-9850214-B2 | Inhibitors of NEDD8-activating enzyme | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2017-12-26 | — | — | US | disclosed |
| US-20150011572-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8809356-B2 | Inhibitors of NEDD8-activating enzyme | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| EP-2748168-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | Millennium Pharmaceuticals, Inc. (US) | 2014-07-02 | — | — | EP | disclosed |
| US-20130150388-A1 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-06-13 | — | — | US | disclosed |
| WO-2013028832-A2 | INHIBITORS OF NEDD8-ACTIVATING ENZYME | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2013-02-28 | — | — | WO | disclosed |
| EP-2298783-A1 | Anti-viral nucleoside analogs and methods for treating viral infections, especially hiv infections | Yale University (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-1032573-A1 | PROCESS FOR PREPARING A CHIRAL NUCLEOSIDE ANALOGUE | GLAXO GROUP LIMITED (GB) | 2000-09-06 | — | — | EP | disclosed |
| US-5973161-A | CATALYTIC CYCLIZING CORRESPONDING LINEAR COMPOUND IN A ORGANIC SOLVENT AT A TEMPERATURE BETWEEN ABOUT-78 DEGREES C AND ABOUT 150 DEGREES C | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1999-10-26 | — | — | US | disclosed |
| WO-1999024431-A1 | PROCESS FOR PREPARING A CHIRAL NUCLEOSIDE ANALOGUE | GLAXO GROUP LIMITED (GB) | 1999-05-20 | — | — | WO | disclosed |
| WO-1999021861-A1 | PROCESS FOR PREPARING A CHIRAL NUCLEOSIDE ANALOGUE | GLAXO GROUP LIMITED (GB) | 1999-05-06 | — | — | WO | disclosed |