Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 11/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 11/20 | 0.44 |
| ▸ | GRIA3 | P42263 | 11/20 | 0.44 |
| ▸ | GRIA4 | P48058 | 11/20 | 0.44 |
| ▸ | GRIK1 | P39086 | 6/20 | 0.43 |
| ▸ | GRIK2 | Q13002 | 6/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 6/20 | 0.43 |
| ▸ | GRIK4 | Q16099 | 6/20 | 0.43 |
| ▸ | GRIK5 | Q16478 | 6/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8114495 | 1.00 | GRIA1 (0.44) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8341491 | 0.91 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8107335 | 0.85 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8122798 | 0.85 | GRIA1 (0.53) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8107468 | 0.82 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8345084 | 0.81 | GRIA1 (0.37) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8180598 | 0.78 | GRIA1 (0.43) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8092046 | 0.76 | GRIA1 (0.41) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8117314 | 0.76 | GRIA1 (0.38) | GRIA1GRIA2GRIA3GRIA4GRIK1 | |
| SCHEMBL8618755 | 0.76 | ALDH1A1 (0.36) | LMNATP53MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696288-B1 | QUINOXALINDIONE DERIVATIVES, THEIR PREPARATION AND THEIR USE IN DRUGS | SCHERING AG (DE) | 2000-09-20 | — | — | EP | disclosed |
| US-5955461-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1999-09-21 | — | — | US | disclosed |
| US-5750525-A | Quinoxalinedione derivatives, their production and use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |