Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.56 |
| ▸ | HTR1A | P08908 | 6/20 | 0.54 |
| ▸ | HTR2C | P28335 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8870607 | 0.99 | SIGMAR1 (0.55) | SIGMAR1HTR1AHTR2CMAPTADRA2A | |
| SCHEMBL8109676 | 0.90 | SIGMAR1 (0.59) | SIGMAR1HTR1AHTR2CMAPT | |
| Hydrochloric Acid SCHEMBL8871359 | 0.89 | SIGMAR1 (0.58) | SIGMAR1HTR1AHTR2C | |
| SCHEMBL9659159 | 0.85 | SIGMAR1 (0.53) | SIGMAR1HTR1AHTR2CMAPTADRA2A | |
| SCHEMBL9437721 | 0.85 | SIGMAR1 (0.53) | SIGMAR1HTR1AHTR2CMAPTADRA2A | |
| Hydrochloric Acid SCHEMBL9437885 | 0.83 | SIGMAR1 (0.52) | SIGMAR1HTR1AHTR2CMAPTADRA2A | |
| SCHEMBL9685737 | 0.83 | SIGMAR1 (0.64) | SIGMAR1HTR1AHTR2CADRA2AADRA2B | |
| SCHEMBL8114236 | 0.82 | SIGMAR1 (0.59) | SIGMAR1HTR1AHTR2CADRA2AADRA2B | |
| SCHEMBL7761420 | 0.82 | SIGMAR1 (0.59) | SIGMAR1HTR1AHTR2CADRA2AADRA2B | |
| Hydrochloric Acid SCHEMBL8871795 | 0.81 | SIGMAR1 (0.57) | SIGMAR1HTR1AHTR2CADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673933-B1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR (FR) | 2000-11-08 | — | — | EP | disclosed |
| CN-1055924-C | Novel aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 2000-08-30 | — | — | CN | disclosed |
| US-5688820-A | NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-11-18 | — | — | US | disclosed |
| US-5688811-A | PSYCHOLOGICAL DISORDERS; NERVOUS SYSTEM DISORDERS | ADIR ET COMPAGNIE (FR) | 1997-11-18 | — | — | US | disclosed |
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| CN-1112114-A | Novel aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and the pharmaceutical compositions which contain them | ADIR (FR) | 1995-11-22 | — | — | CN | disclosed |
| EP-0673933-A1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | disclosed |
| US-5296477-A | Antidepressants | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| US-5268381-A | Antidepressant or anxiolytic compound | ADIR ET COMPAGNIE (FR) | 1993-12-07 | — | — | US | disclosed |
| US-5196434-A | Antidepressants, anxiolytic agents | ADIR ET COMPAGNIE (FR) | 1993-03-23 | — | — | US | disclosed |
| EP-0478446-A1 | Heterocyclic alkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-04-01 | — | — | EP | disclosed |