Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.68 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.68 |
| ▸ | LTA4H | P09960 | 8/20 | 0.65 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
| ▸ | KDM1A | O60341 | 1/20 | 0.57 |
| ▸ | HRH2 | P25021 | 1/20 | 0.56 |
| ▸ | HRH1 | P35367 | 1/20 | 0.56 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6943925 | 1.00 | TMEM97 (0.68) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL6948464 | 0.93 | TMEM97 (0.67) | TMEM97SIGMAR1LTA4HHTR1AHRH2 | |
| SCHEMBL8109504 | 0.93 | TMEM97 (0.67) | TMEM97SIGMAR1LTA4HHTR1AHRH2 | |
| SCHEMBL4729812 | 0.90 | LTA4H (0.79) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL4729810 | 0.90 | LTA4H (0.79) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL7142393 | 0.88 | LTA4H (0.85) | LTA4H | |
| SCHEMBL3571383 | 0.85 | TMEM97 (0.71) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL98426 | 0.85 | LTA4H (0.66) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL7074526 | 0.85 | TMEM97 (0.66) | TMEM97SIGMAR1LTA4HHTR1AHTR7 | |
| SCHEMBL5388793 | 0.85 | HRH3 (0.71) | TMEM97SIGMAR1LTA4HHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056744-A1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043675-A1 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |