Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTAFR | P25105 | 2/20 | 0.38 |
| ▸ | THRA | P10827 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.38 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9829388 | 0.85 | ALDH1A1 (0.48) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL8109837 | 0.81 | ALDH1A1 (0.44) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL8109869 | 0.80 | BPTF (0.56) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL9691519 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2MEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL8886466 | 0.77 | ALDH1A1 (0.43) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL8109885 | 0.76 | PTAFR (0.61) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL9100958 | 0.76 | NPC1 (0.48) | SMN1; SMN2KMT2ARAB9A | |
| SCHEMBL9690039 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2RAB9AL3MBTL1 | |
| SCHEMBL9828738 | 0.75 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A | |
| SCHEMBL10448821 | 0.75 | PTAFR (0.57) | ALDH1A1SMN1; SMN2KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650485-B1 | 2,5-DIARYL TETRAHYDRO-THIOPHENES, -FURANS AND ANALOGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED INC (US) | 2000-10-11 | — | — | EP | disclosed |
| US-5856323-A | PAF RECEPTOR ANTAGONISTS, INHIBITING THE ENZYME 5-LIPOXYGENASE | CYTOMED, INC. (US) | 1999-01-05 | — | — | US | disclosed |
| US-5434151-A | Treatment of immune and inflammatory disorders, aryl substituted tetrahydrofurans, tetrahydrothiophenes, cyclopentanes, pyrrolidines | CYTOMED, INC. (US) | 1995-07-18 | — | — | US | disclosed |
| EP-0650485-A1 | 2,5-DIARYL TETRAHYDRO-THIOPHENES, -FURANS AND ANALOGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED, INC. (US) | 1995-05-03 | — | — | EP | disclosed |
| US-5358938-A | 2,5-Diaryl tetrahydrofurans, tetrahydrothiophenes, 1,3-cyclo-pentanes and pyrrolidines | CYTOMED, INC. (US) | 1994-10-25 | — | — | US | disclosed |
| WO-1994001430-A1 | 2,5-DIARYL TETRAHYDRO-THIOPHENES, -FURANS AND ANALOGS FOR THE TREATMENT OF INFLAMMATORY AND IMMUNE DISORDERS | CYTOMED, INC. (US) | 1994-01-20 | — | — | WO | disclosed |