Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 7/20 | 0.74 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.74 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.74 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.74 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.74 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.74 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.74 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4675791 | 0.94 | GRIN1 (0.71) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8109896 | 0.90 | GRIN1 (0.69) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL6163233 | 0.86 | GRIN2B (0.69) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL1908150 | 0.84 | GRIN2B (1.00) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4674306 | 0.84 | GRIN2B (0.68) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| Besonprodil SCHEMBL29388542 | 0.83 | GRIN1 (0.66) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| Besonprodil SCHEMBL2257896 | 0.83 | GRIN1 (0.66) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8100582 | 0.83 | GRIN1 (0.66) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4674624 | 0.83 | GRIN1 (0.62) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL3445998 | 0.82 | GRIN2D (0.73) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0673933-B1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR (FR) | 2000-11-08 | — | — | EP | disclosed |
| US-5534511-A | AFFINITY FOR SIGMA RECEPTORS, ANTIINFLAMMATORY, TREATMENT OF ARTHRITIS | ADIR ET COMPAGNIE (FR) | 1996-07-09 | — | — | US | disclosed |
| EP-0673933-A1 | Aminoalkyl benzoxazolinones and benzothiazolinones process for their preparation and compositions containing them | ADIR ET COMPAGNIE (FR) | 1995-09-27 | — | — | EP | disclosed |