Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 5/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 5/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 3/20 | 1.00 |
| ▸ | GRIN3B | O60391 | 3/20 | 1.00 |
| ▸ | GRIN2A | Q12879 | 3/20 | 1.00 |
| ▸ | GRIN2C | Q14957 | 3/20 | 1.00 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 1.00 |
| ▸ | ENPP2 | Q13822 | 4/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546370 | 0.90 | GRIN1 (0.82) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7528460 | 0.88 | GRIN2B (0.79) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL109647 | 0.86 | GRIN2B (0.76) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7418720 | 0.85 | GRIN2B (0.74) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL3445998 | 0.84 | GRIN2D (0.73) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8542333 | 0.84 | GRIN2B (0.73) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL8109942 | 0.84 | GRIN1 (0.74) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7529124 | 0.83 | GRIN2B (0.70) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL7531038 | 0.83 | GRIN1 (0.70) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A | |
| SCHEMBL4675791 | 0.82 | GRIN1 (0.71) | GRIN2BGRIN1GRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1649857-A2 | New use of glutamate antagonists for the treatment of cancer | Ikonomidou, Hrissanthi (DE) | 2006-04-26 | — | — | EP | claimed |
| US-20050054650-A1 | Use of glutamate antagonists for the treatment of cancer | IKONOMIDOU HRISSANTHI (DE) | 2005-03-10 | — | — | US | claimed |
| WO-2002030422-A1 | USE OF DEFINED SUBSTANCES THAT BIND TO THE SIGMA RECEPTOR FOR COMBATING SARCOMA AND CARCINOMA | MERCK PATENT GMBH (DE) | 2002-04-18 | — | — | WO | claimed |
| EP-1124553-A1 | NEW USE OF GLUTAMATE ANTAGONISTS FOR THE TREATMENT OF CANCER | Ikonomidou, Hrissanthi (DE) | 2001-08-22 | — | — | EP | claimed |
| EP-1002535-A1 | New use of glutamate antagonists for the treatment of cancer | Ikonomidou, Hrissanthi (DE) | 2000-05-24 | — | — | EP | claimed |
| WO-2000024395-A1 | NEW USE OF GLUTAMATE ANTAGONISTS FOR THE TREATMENT OF CANCER | IKONOMIDOU HRISSANTHI (DE) | 2000-05-04 | — | — | WO | claimed |
| EP-0938485-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GmbH (DE) | 1999-09-01 | — | — | EP | claimed |
| WO-1998018793-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GMBH (DE) | 1998-05-07 | — | — | WO | claimed |
| US-20130281523-A1 | LOW DOSE CANNABINOID MEDICAMENTS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS | 2013-10-24 | — | — | US | disclosed |
| EP-2640379-A2 | LOW DOSE CANNABINOID MEDICAMENTS | Pier Pharmaceuticals (US) | 2013-09-25 | — | — | EP | disclosed |
| US-20120231083-A1 | SUSTAINED RELEASE CANNABINOID MEDICAMENTS | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2012-09-13 | — | — | US | disclosed |
| WO-2012068516-A2 | LOW DOSE CANNABINOID MEDICAMENTS | PIER PHARMACEUTICALS (US) | 2012-05-24 | — | — | WO | disclosed |
| US-8178496-B2 | Photoreactive regulator of glutamate receptor function and methods of use thereof | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2012-05-15 | — | — | US | disclosed |
| WO-2011063164-A2 | SUSTAINED RELEASE CANNABINOID MEDICAMENTS | STEADY SLEEP RX CO., INC. (US) | 2011-05-26 | — | — | WO | disclosed |
| EP-0938485-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GmbH (DE) | 1999-09-01 | — | — | EP | disclosed |
| EP-0938485-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GmbH (DE) | 1999-09-01 | — | — | EP | disclosed |
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1998018793-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GMBH (DE) | 1998-05-07 | — | — | WO | disclosed |
| WO-1998018793-A1 | BENZOXAZOLE DERIVATIVE WITH AN AFFINITY TO BINDING SITES OF AMINO ACID RECEPTORS | MERCK PATENT GMBH (DE) | 1998-05-07 | — | — | WO | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |