SCHEMBL8109950

SCHEMBL8109950

CN1CCN(c2ccnc3ccc(NC(=O)Nc4ccnc5ccccc45)cc23)CC1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2C P28335 8/20 0.67
HTR2B P41595 8/20 0.67
ADRA2A P08913 1/20 0.54
ADRA2B P18089 1/20 0.54
ADRA2C P18825 1/20 0.54
MAPT P10636 7/20 0.53
TP53 P04637 6/20 0.52
POLB P06746 1/20 0.49
BLM P54132 1/20 0.49
PDGFRB P09619 1/20 0.48
LMNA P02545 2/20 0.47
MAPKAPK2 P49137 1/20 0.46
THRB P10828 1/20 0.46
KDR P35968 2/20 0.46
KIT P10721 1/20 0.46
PDGFRA P16234 1/20 0.46
PLK4 O00444 1/20 0.46
CHEK1 O14757 1/20 0.46
PDPK1 O15530 1/20 0.46
PRKD3 O94806 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8111836 0.94 HTR2B (0.60) HTR2CHTR2BADRA2AADRA2BADRA2C
SCHEMBL8101874 0.91 HTR2C (0.56) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8117854 0.88 MAPT (0.66) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8110484 0.88 HTR2C (0.53) HTR2CHTR2BADRA2AADRA2BADRA2C
SCHEMBL8101977 0.88 MAPT (0.56) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8101916 0.87 HTR2C (0.52) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8109870 0.87 HTR2C (0.52) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8113092 0.87 MAPT (0.58) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8118113 0.86 MAPT (0.55) HTR2CHTR2BMAPTTP53POLB
SCHEMBL8112138 0.86 HTR2C (0.51) HTR2CHTR2BADRA2AADRA2BADRA2C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP claimed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO claimed
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed