SCHEMBL8101977

SCHEMBL8101977

CN1CCN(c2ccnc3ccc(NC(=O)Nc4cccc5c(Br)cccc45)cc23)CC1

nearest known ligand 0.56

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
MAPT P10636 12/20 0.56
TP53 P04637 9/20 0.56
HTR2C P28335 4/20 0.52
HTR2B P41595 4/20 0.52
POLB P06746 2/20 0.46
BLM P54132 1/20 0.46
LMNA P02545 3/20 0.44
MAP3K7 O43318 1/20 0.44
THRB P10828 1/20 0.43
KIT P10721 1/20 0.43
PDGFRA P16234 1/20 0.43
KDR P35968 1/20 0.43
MALT1 Q9UDY8 1/20 0.42
HTR1A P08908 1/20 0.42
HTR1D P28221 1/20 0.42
HTR1B P28222 1/20 0.42
HTR2A P28223 1/20 0.42
HTR7 P34969 1/20 0.42
HTR6 P50406 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8117854 0.92 MAPT (0.66) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8110484 0.91 HTR2C (0.53) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8111836 0.90 HTR2B (0.60) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8101817 0.89 NCF1 (0.52) MAPTTP53HTR2CHTR2BHTR1A
SCHEMBL8101874 0.89 HTR2C (0.56) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8101916 0.88 HTR2C (0.52) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8109870 0.88 HTR2C (0.52) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8109950 0.88 HTR2C (0.67) MAPTTP53HTR2CHTR2BPOLB
SCHEMBL8112872 0.87 BACE1 (0.44) MAPTTP53HTR2CHTR2B
SCHEMBL8138002 0.86 HTR2C (0.50) MAPTTP53HTR2CHTR2BPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP claimed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO claimed
EP-1047691-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 2000-11-02 EP disclosed
WO-1999031086-A1 QUINOLINEPIPERAZINE AND QUINOLINEPIPERIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS COMBINED 5-HT1A, 5-HT1B AND 5-HT1D RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM PLC (GB) 1999-06-24 WO disclosed