Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 5/20 | 0.39 |
| ▸ | F2 | P00734 | 12/20 | 0.36 |
| ▸ | PLG | P00747 | 3/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.36 |
| ▸ | KLK1 | P06870 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | F10 | P00742 | 9/20 | 0.35 |
| ▸ | F7 | P08709 | 3/20 | 0.35 |
| ▸ | TMPRSS6 | Q8IU80 | 1/20 | 0.34 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.31 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.31 |
| ▸ | C1S | P09871 | 1/20 | 0.31 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1624373 | 0.85 | PLAU (0.40) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL1624025 | 0.78 | F10 (0.39) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL1624418 | 0.73 | F10 (0.38) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL1624971 | 0.67 | F2 (0.37) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL1623823 | 0.67 | PLAU (0.45) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL8118334 | 0.67 | PRSS1 (0.40) | PLAUF2PRSS1F10PRSS2 | |
| SCHEMBL1624029 | 0.64 | F10 (0.39) | PLAUF2PLGPRSS1KLKB1 | |
| SCHEMBL8127509 | 0.62 | PRSS1 (0.41) | PLAUF2PRSS1F10TMPRSS6 | |
| SCHEMBL8120426 | 0.61 | ADRA2C (0.35) | PLAUF2PLGPRSS1F10 | |
| SCHEMBL8125654 | 0.61 | ADRA2C (0.35) | PLAUF2PLGPRSS1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1009758-A1 | META-BENZAMIDINE DERIVATIVES AS SERINE PROTEASE INHIBITORS | Protherics Molecular Design Limited (GB) | 2000-06-21 | — | — | EP | disclosed |
| WO-1999011658-A1 | META-BENZAMIDINE DERIVATIVES AS SERIN PROTEASE INHIBITORS | PROTEUS MOLECULAR DESIGN LTD. (GB) | 1999-03-11 | — | — | WO | disclosed |