Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 12/20 | 0.58 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR7 | P34969 | 3/20 | 0.51 |
| ▸ | HTR6 | P50406 | 3/20 | 0.51 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 1/20 | 0.51 |
| ▸ | HTR1B | P28222 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 1/20 | 0.51 |
| ▸ | CTSK | P43235 | 1/20 | 0.51 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.51 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17464549 | 0.87 | CDK2 (0.55) | CDK2HTR2AHTR7HTR6MPO | |
| SCHEMBL8050581 | 0.82 | CDK2 (0.55) | CDK2HTR2AHTR7HTR6HTR1A | |
| SCHEMBL8265688 | 0.80 | MEN1 (0.55) | CDK2HTR2AHTR7HTR6HTR1A | |
| SCHEMBL8048284 | 0.79 | HTR2A (0.56) | CDK2HTR2AHTR7HTR6MPO | |
| SCHEMBL8263255 | 0.79 | HTR2A (0.65) | HTR2AHTR7HTR6MPOCYP1A2 | |
| SCHEMBL28384834 | 0.78 | HTR2A (0.66) | CDK2HTR2AHTR7HTR6MPO | |
| SCHEMBL4786975 | 0.78 | HTR2A (0.55) | CDK2HTR2AHTR7HTR6MPO | |
| SCHEMBL18783077 | 0.77 | CDK2 (0.55) | CDK2HTR2ACYP1A2HTR1AHTT | |
| SCHEMBL8041168 | 0.76 | HTR2A (0.56) | CDK2HTR2AHTR7HTR6CYP1A2 | |
| SCHEMBL8041585 | 0.74 | POLB (0.59) | CDK2HTR2AHTR7HTR6MPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132155-A2 | INHIBITORS OF THE BINDING BETWEEN HDM2 AND THE PROTEASOME | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-06 | — | — | WO | disclosed |