Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR6 | P50406 | 3/20 | 0.55 |
| ▸ | HTR1A | P08908 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.55 |
| ▸ | HTR7 | P34969 | 2/20 | 0.55 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | DRD1 | P21728 | 1/20 | 0.51 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | DRD5 | P21918 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | CDK2 | P24941 | 2/20 | 0.50 |
| ▸ | GOT1 | P17174 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MC5R | P33032 | 1/20 | 0.50 |
| ▸ | MC3R | P41968 | 1/20 | 0.50 |
| ▸ | MC1R | Q01726 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8263255 | 0.81 | HTR2A (0.65) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL28379250 | 0.79 | MC5R (0.64) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL6599683 | 0.78 | HTR2A (0.71) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL8111483 | 0.78 | CDK2 (0.58) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL8050581 | 0.77 | CDK2 (0.55) | HTR2AHTR6HTR1ADRD2HTR7 | |
| Hydrochloric Acid SCHEMBL11602872 | 0.77 | HTR2A (0.70) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL19778568 | 0.76 | HRH3 (0.67) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL8048284 | 0.76 | HTR2A (0.56) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL23341977 | 0.76 | HTR2A (0.56) | HTR2AHTR6HTR1ADRD2HTR7 | |
| SCHEMBL7015692 | 0.76 | HRH3 (0.67) | HTR2AHTR6HTR1ADRD2HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008132155-A2 | INHIBITORS OF THE BINDING BETWEEN HDM2 AND THE PROTEASOME | JANSSEN PHARMACEUTICA NV (BE) | 2008-11-06 | — | — | WO | disclosed |