Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.44 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10669295 | 0.87 | CYSLTR1 (0.57) | PDE10ACYSLTR1CYSLTR2GPBAR1NPC1 | |
| SCHEMBL27595473 | 0.84 | SMN1; SMN2 (0.51) | PDE10ACYSLTR1CYSLTR2NPC1RAB9A | |
| SCHEMBL8108135 | 0.84 | CYSLTR1 (0.44) | PDE10ACYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL7508073 | 0.82 | CYSLTR1 (0.46) | PDE10ACYSLTR1CYSLTR2GPBAR1NPC1 | |
| SCHEMBL8098339 | 0.76 | CYSLTR1 (0.76) | PDE10ACYSLTR1CYSLTR2GPBAR1FFAR1 | |
| SCHEMBL30824487 | 0.75 | TSHR (0.41) | PDE10ACYSLTR1CYSLTR2SMN1; SMN2ALOX5 | |
| SCHEMBL10376026 | 0.75 | MAOB (0.53) | PDE10ACYSLTR1CYSLTR2GPBAR1NPC1 | |
| SCHEMBL7148696 | 0.73 | CYSLTR1 (0.41) | PDE10ACYSLTR1CYSLTR2GPBAR1LMNA | |
| SCHEMBL8144813 | 0.73 | CYSLTR1 (0.66) | PDE10ACYSLTR1CYSLTR2GPBAR1SMN1; SMN2 | |
| SCHEMBL7509513 | 0.73 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2GPBAR1SMN1; SMN2ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |