Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 7/20 | 0.42 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112158 | 0.84 | PDE10A (0.47) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10669295 | 0.83 | CYSLTR1 (0.57) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10376026 | 0.83 | MAOB (0.53) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL7509513 | 0.81 | CYSLTR1 (0.49) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL8144813 | 0.81 | CYSLTR1 (0.66) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10378235 | 0.79 | CYSLTR1 (0.69) | CYSLTR1GPBAR1 | |
| SCHEMBL6744402 | 0.78 | CYSLTR1 (0.69) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL21981570 | 0.78 | ABCB1 (0.40) | CYSLTR1CYSLTR2GPBAR1PDE10A | |
| SCHEMBL10376027 | 0.78 | CYSLTR1 (0.46) | CYSLTR1CYSLTR2GPBAR1 | |
| SCHEMBL10375902 | 0.78 | CYP1A2 (0.56) | CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |