Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 12/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.40 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107445 | 0.85 | LTA4H (0.62) | LTA4HEGFRERBB2HCRTR2CYSLTR2 | |
| Hydrochloric Acid SCHEMBL8107416 | 0.84 | LTA4H (0.61) | LTA4HEGFRERBB2HCRTR2CYSLTR2 | |
| SCHEMBL5685387 | 0.84 | LTA4H (0.69) | LTA4HHCRTR2NPC1POLBRAB9A | |
| SCHEMBL8710875 | 0.77 | LTA4H (0.49) | LTA4HEGFRERBB2CYSLTR2CYSLTR1 | |
| Hydrochloric Acid SCHEMBL8711512 | 0.76 | LTA4H (0.49) | LTA4HEGFRERBB2CYSLTR2CYSLTR1 | |
| SCHEMBL8107892 | 0.73 | LTA4H (0.76) | LTA4HNPC1POLBRAB9A | |
| Hydrochloric Acid SCHEMBL8107928 | 0.73 | LTA4H (0.58) | LTA4HHCRTR2NPC1POLBRAB9A | |
| SCHEMBL2108222 | 0.73 | LTA4H (1.00) | LTA4H | |
| SCHEMBL2108981 | 0.73 | LTA4H (1.00) | LTA4HACHE | |
| SCHEMBL5685382 | 0.73 | LTA4H (0.72) | LTA4HACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6162823-A | LTA4 hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2000-12-19 | — | — | US | claimed |
| WO-1998040354-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | claimed |
| US-6162823-A | LTA4 hydrolase inhibitors | G.D. SEARLE & CO. (US) | 2000-12-19 | — | — | US | disclosed |
| WO-1998040354-A1 | LTA4 HYDROLASE INHIBITORS | G.D. SEARLE & CO. (US) | 1998-09-17 | — | — | WO | disclosed |