Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | PDE4A | P27815 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.45 |
| ▸ | CXCR1 | P25024 | 4/20 | 0.45 |
| ▸ | CXCR2 | P25025 | 4/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.45 |
| ▸ | ALB | P02768 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8127426 | 1.00 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL1966513 | 0.89 | CXCR1 (0.53) | CHRM1PDE4AFAAHCXCR1CXCR2 | |
| SCHEMBL8121698 | 0.85 | TTR (0.46) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8121695 | 0.85 | TTR (0.46) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8114190 | 0.85 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8114187 | 0.85 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL9576148 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7185145 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7185147 | 0.82 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL4355522 | 0.81 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519353-B1 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-5334716-A | Preventing testosteron 5a-reductase mediated diseases; alopecia, acne, prostatism | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0519353-A2 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |