Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | FAAH | O00519 | 3/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4355525 | 1.00 | NPC1 (0.67) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL25524702 | 0.84 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL764948 | 0.84 | KDM4E (0.61) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL7825300 | 0.84 | KDM4E (0.61) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL25516475 | 0.83 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8112968 | 0.81 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8127426 | 0.81 | NPC1 (0.50) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL19737658 | 0.81 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL26092551 | 0.81 | SMN1; SMN2 (0.64) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL6836595 | 0.80 | LMNA (0.56) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1982716-B1 | NOVEL HISTIDINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2013-04-03 | — | — | EP | disclosed |
| US-8236844-B2 | Histidine derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2012-08-07 | — | — | US | disclosed |
| US-20090149658-A1 | Novel Histidine Derivatives | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2009-06-11 | — | — | US | disclosed |
| EP-1982716-A1 | NOVEL HISTIDINE DERIVATIVE | Nippon Zoki Pharmaceutical Co. Ltd. (JP) | 2008-10-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090149658-A1 | Novel Histidine Derivatives | HRH4, HNMT, HRH3 | NPC1 3166/4885RAB9A 2684/4885SMN1; SMN2 2374/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.