Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 5/20 | 0.61 |
| ▸ | UNG | P13051 | 1/20 | 0.49 |
| ▸ | FBP1 | P09467 | 1/20 | 0.48 |
| ▸ | P4HB | P07237 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.45 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.43 |
| ▸ | MEP1B | Q16820 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALB | P02768 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8112605 | 1.00 | TTR (0.61) | TTRUNGFBP1P4HBNPC1 | |
| SCHEMBL9372275 | 1.00 | TTR (0.61) | TTRUNGFBP1P4HBNPC1 | |
| SCHEMBL8121695 | 0.87 | TTR (0.46) | TTRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8121698 | 0.87 | TTR (0.46) | TTRNPC1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL8120717 | 0.85 | P4HB (0.51) | TTRP4HBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8114187 | 0.85 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL8114190 | 0.85 | NPC1 (0.51) | NPC1RAB9ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL9373781 | 0.83 | TTR (0.48) | TTRRAB9AKMT2A | |
| SCHEMBL9373774 | 0.83 | TTR (0.48) | TTRRAB9AKMT2A | |
| SCHEMBL13926057 | 0.83 | TTR (0.86) | TTRUNGFBP1P4HBSRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519353-B1 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-5334716-A | Preventing testosteron 5a-reductase mediated diseases; alopecia, acne, prostatism | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0519353-A2 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |