Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.46 |
| ▸ | NPC1 | O15118 | 8/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5342718 | 0.84 | NPC1 (0.46) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL19617714 | 0.82 | NPC1 (0.53) | RAB9ANPC1SMN1; SMN2MAPTLMNA | |
| SCHEMBL10219276 | 0.82 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2POLBMAPT | |
| SCHEMBL10219277 | 0.82 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2POLBMAPT | |
| SCHEMBL10219282 | 0.82 | NPC1 (0.52) | RAB9ANPC1SMN1; SMN2POLBMAPT | |
| SCHEMBL10219283 | 0.79 | PPARD (0.51) | CYP2D6PPARG | |
| SCHEMBL10219278 | 0.79 | PPARD (0.51) | CYP2D6PPARG | |
| SCHEMBL10219295 | 0.79 | PPARD (0.51) | CYP2D6PPARG | |
| SCHEMBL9033466 | 0.79 | RAB9A (0.49) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 | |
| SCHEMBL23744657 | 0.78 | RAB9A (0.43) | RAB9ANPC1SMN1; SMN2POLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |