⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115125 | 1.00 | — | — | |
| SCHEMBL11105098 | 0.81 | ALDH1A1 (0.56) | — | |
| SCHEMBL11105090 | 0.81 | ALDH1A1 (0.56) | — | |
| SCHEMBL11525466 | 0.78 | — | — | |
| SCHEMBL11525463 | 0.78 | — | — | |
| SCHEMBL31559245 | 0.74 | — | — | |
| SCHEMBL11525791 | 0.74 | — | — | |
| SCHEMBL11525793 | 0.74 | — | — | |
| SCHEMBL17503298 | 0.73 | — | — | |
| SCHEMBL5083578 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0723546-B1 | 1,2,4 - TRIZOLO[1,5-a]PYRIMIDINE AND THEIR USE FOR TREATMENT OF NEUROLOGICAL DISORDERS | KNOLL AG (DE) | 2000-01-19 | — | — | EP | disclosed |
| CN-1040537-C | Substituted 1,2, 4-triazolo [1,5-a] pyrimidines, processes for their preparation and pharmaceutical compositions containing them | KNOLL AG (DE) | 1998-11-04 | — | — | CN | disclosed |
| US-5753665-A | TRIAZOLOPYRIMIDINES, NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-05-19 | — | — | US | disclosed |
| CN-1135754-A | Therapeutic agents | KNOLL AG (DE) | 1996-11-13 | — | — | CN | disclosed |
| US-4161608-A | 11 Hydroxy methyl 11-deoxyprostaglandin E1 | AYERST, MCKENNA AND HARRISON LIMITED (CA) | 1979-07-17 | — | — | US | disclosed |
| US-4100343-A | 11-Deoxyprostaglandin derivatives | AYERST, MCKENNA & HARRISON LIMITED (CA) | 1978-07-11 | — | — | US | disclosed |
| US-4093720-A | ANTIALDOSTERONE AGENTS | ROUSSEL UCLAF (FR) | 1978-06-06 | — | — | US | disclosed |
| US-4089898-A | 11-Deoxyprostaglandin derivatives | AYERST, MCKENNA & HARRISON LTD. (CA) | 1978-05-16 | — | — | US | disclosed |
| US-4048271-A | Dry process for forming polycarbonate membranes | CHEMICAL SYSTEMS, INC. (US) | 1977-09-13 | — | — | US | disclosed |
| US-4036856-A | PROSTAGLANDINS | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-07-19 | — | — | US | disclosed |
| US-4006136-A | Prostaglandin intermediates | AYERST MCKENNA AND HARRISON LTD. (CA) | 1977-02-01 | — | — | US | disclosed |
| US-3945926-A | Integral microporous high void volume polycarbonate membranes and a dry process for forming same | CHEMICAL SYSTEMS, INC. (US) | 1976-03-23 | — | — | US | disclosed |