Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 8/20 | 0.37 |
| ▸ | HTR4 | Q13639 | 8/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8119964 | 1.00 | CCR5 (0.39) | CCR5MEN1KMT2AACHEHTR4 | |
| SCHEMBL8116754 | 0.92 | SPHK1 (0.38) | MEN1KMT2AACHEHTR4NPC1 | |
| SCHEMBL8838795 | 0.90 | MEN1 (0.39) | CCR5MEN1KMT2ANPC1GAA | |
| SCHEMBL8119961 | 0.90 | ANO1 (0.40) | MEN1KMT2AACHEHTR4NPC1 | |
| SCHEMBL8114129 | 0.83 | AAK1 (0.36) | MEN1KMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8122289 | 0.83 | NPC1 (0.40) | MEN1KMT2AACHEHTR4NPC1 | |
| SCHEMBL8124172 | 0.82 | ANO1 (0.38) | CCR5MEN1KMT2AACHEGAA | |
| SCHEMBL8110363 | 0.82 | SPHK1 (0.36) | MEN1KMT2A | |
| SCHEMBL8118247 | 0.82 | ANO1 (0.39) | MEN1KMT2ANPC1RAB9A | |
| SCHEMBL8115980 | 0.81 | MAPT (0.38) | CCR5MEN1KMT2AGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0632036-B1 | Amide derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO CO (JP) | 2000-03-01 | — | — | EP | disclosed |
| US-5614550-A | ANTICHOLESTEROL AGENTS OR ARTERIOSCLEROSIS AGENTS FOR HUMANS | SANKYO COMPANY, LIMITED (JP) | 1997-03-25 | — | — | US | disclosed |
| US-5534529-A | Substituted aromatic amides and ureas derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 1996-07-09 | — | — | US | disclosed |
| EP-0632036-A2 | Amide and urea derivatives having anti-hypercholesteremic activity, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1995-01-04 | — | — | EP | disclosed |