Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICAM1 | P05362 | 10/20 | 0.61 |
| ▸ | SELE | P16581 | 10/20 | 0.61 |
| ▸ | VCAM1 | P19320 | 4/20 | 0.61 |
| ▸ | PIM1 | P11309 | 9/20 | 0.58 |
| ▸ | GSK3A | P49840 | 9/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 9/20 | 0.58 |
| ▸ | KDR | P35968 | 8/20 | 0.58 |
| ▸ | LIMK1 | P53667 | 8/20 | 0.58 |
| ▸ | GSK3B | P49841 | 8/20 | 0.58 |
| ▸ | CDK2 | P24941 | 8/20 | 0.58 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.58 |
| ▸ | CDK1 | P06493 | 7/20 | 0.58 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.58 |
| ▸ | MAPK9 | P45984 | 7/20 | 0.58 |
| ▸ | CSNK1D | P48730 | 7/20 | 0.58 |
| ▸ | RPS6KA3 | P51812 | 6/20 | 0.58 |
| ▸ | DAPK3 | O43293 | 6/20 | 0.58 |
| ▸ | PRKACA | P17612 | 6/20 | 0.58 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.58 |
| ▸ | FGFR3 | P22607 | 6/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15518133 | 0.80 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL29069393 | 0.78 | ICAM1 (0.69) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL30568694 | 0.76 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL742713 | 0.76 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL14023789 | 0.76 | ICAM1 (0.67) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL7054697 | 0.76 | ICAM1 (1.00) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL7056141 | 0.75 | ICAM1 (0.65) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL7056743 | 0.74 | GSK3A (1.00) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL7053404 | 0.72 | PIM1 (0.69) | ICAM1SELEVCAM1PIM1GSK3A | |
| SCHEMBL5555786 | 0.72 | PIM1 (0.78) | ICAM1SELEVCAM1PIM1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008144463-A1 | QUINOLINE DERIVATIVES AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-11-27 | — | — | WO | disclosed |