Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 8/20 | 0.60 |
| ▸ | RARA | P10276 | 7/20 | 0.60 |
| ▸ | RARG | P13631 | 7/20 | 0.60 |
| ▸ | RXRA | P19793 | 7/20 | 0.46 |
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRG | P48443 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | CYP26A1 | O43174 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116844 | 0.92 | RARB (0.60) | RARBRARARARGRXRARXRB | |
| SCHEMBL8116895 | 0.90 | RARB (0.62) | RARBRARARARGRXRARXRB | |
| SCHEMBL8115008 | 0.88 | RARA (0.65) | RARBRARARARGHDAC1HDAC6 | |
| SCHEMBL8107181 | 0.84 | RARA (0.53) | RARBRARARARGRXRARXRB | |
| SCHEMBL8116218 | 0.84 | RARA (0.53) | RARBRARARARGRXRARXRB | |
| SCHEMBL8122124 | 0.81 | RARA (0.61) | RARBRARARARGRXRARXRB | |
| SCHEMBL7712308 | 0.80 | RARA (0.58) | RARBRARARARGMEN1KMT2A | |
| SCHEMBL8116015 | 0.78 | RARB (0.64) | RARBRARARARGRXRARXRB | |
| SCHEMBL8114657 | 0.78 | RARA (0.55) | RARBRARARARGRXRARXRB | |
| SCHEMBL7706883 | 0.78 | RARA (0.67) | RARBRARARARGMEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6127382-A | AN ANTIPROLIFERATIVE AGENT FOR TREATING SKIN-RELATED DISEASES, AN ANTITUMOR AGENT TREATING CANCER, AN ANTIINFLAMMATORY AGENT TREATING PULMONARY FIBROSIS, ILEITIS, COLITIS AND KROHN'S DISEASE | ALLERGAN SALES, INC. (US) | 2000-10-03 | — | — | US | disclosed |