Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 5/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120811 | 0.85 | CCR3 (0.59) | CCR3CHRM2MEN1KMT2APDE4B | |
| SCHEMBL8121833 | 0.84 | PDE4B (0.50) | MEN1KMT2APDE4BCYP2C9CYP2C19 | |
| SCHEMBL8115032 | 0.83 | PDE4B (0.61) | MEN1KMT2APDE4BCYP2C9CYP2C19 | |
| SCHEMBL8121936 | 0.83 | CYP2C9 (0.48) | CHRM2MEN1KMT2APDE4BCYP2C9 | |
| SCHEMBL8106334 | 0.83 | TRPC6 (0.50) | MEN1KMT2APDE4BCYP2C9CYP2C19 | |
| SCHEMBL8121034 | 0.81 | CCR3 (0.58) | CCR3MEN1KMT2APDE4BCYP2C9 | |
| SCHEMBL8119965 | 0.81 | CCR3 (0.58) | CCR3CHRM2MEN1KMT2APDE4B | |
| SCHEMBL8122481 | 0.81 | MEN1 (0.48) | MEN1KMT2APDE4BCYP2C9CYP2C19 | |
| SCHEMBL8120528 | 0.81 | PDE4B (0.59) | PDE4B | |
| SCHEMBL8123484 | 0.81 | PDE4B (0.48) | PDE4BMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831090-B1 | N-substituted cyclic amines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 2000-04-12 | — | — | EP | disclosed |
| US-5919801-A | N-substituted piperidines as PDE4 inhibitors | ADIR ET COMPAGNIE (FR) | 1999-07-06 | — | — | US | disclosed |
| EP-0831090-A1 | N-substituted cyclic amines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1998-03-25 | — | — | EP | disclosed |