Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.40 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.40 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.31 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.31 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.31 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.31 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8125480 | 0.90 | TXNRD1 (0.39) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL10305220 | 0.90 | TXNRD1 (0.39) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL3027768 | 0.89 | MAPT (0.39) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL3029367 | 0.89 | MAPT (0.39) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL13222372 | 0.87 | MAPT (0.44) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL3037529 | 0.87 | TXNRD1 (0.36) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL4361272 | 0.87 | TXNRD1 (0.36) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL3039471 | 0.87 | TXNRD1 (0.36) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL4523570 | 0.87 | TXNRD1 (0.36) | TXNRD1TXNRD3TXNRD2NPC1RAB9A | |
| SCHEMBL492529 | 0.85 | TXNRD1 (0.41) | TXNRD1TXNRD3TXNRD2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008118935-A1 | COMPOUNDS AND PROCESSES FOR PREPARING SUBSTITUTED AMINOMETHYL-2,3,8,9-TETRAHYDRO-7H-1,4-DIOXINO[2,3-E]INDOL-8-ONES | NEUROGEN CORPORATION (US) | 2008-10-02 | — | — | WO | disclosed |