Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 7/20 | 0.70 |
| ▸ | HTR3B | O95264 | 5/20 | 0.60 |
| ▸ | HTR3A | P46098 | 5/20 | 0.60 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.60 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.60 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116881 | 0.88 | HRH4 (0.54) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21208503 | 0.78 | HTR3B (0.65) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21208427 | 0.75 | HRH4 (0.52) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL8111177 | 0.75 | HTR3E (1.00) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL12225319 | 0.75 | MAPT (0.76) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL406010 | 0.75 | HRH4 (1.00) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21208502 | 0.74 | HTR3E (0.62) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21208545 | 0.74 | HRH4 (0.54) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL21208572 | 0.73 | HRH4 (0.59) | HRH4HTR3BHTR3AHTR3EHTR3D | |
| SCHEMBL8117461 | 0.73 | TYMS (0.57) | MAPTGAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124287-A | TREATING DEPRESSION | BIOMEDICA FOSCAMA INDUSTRIA CHIMICOFARMACEUTICA S.P.A. (IT) | 2000-09-26 | — | — | US | disclosed |
| EP-0865442-B1 | IMIDAZO[1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOSCAMA BIOMED CHIM FARMA (IT) | 2000-07-05 | — | — | EP | disclosed |