Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.47 |
| ▸ | CA2 | P00918 | 3/20 | 0.47 |
| ▸ | CA7 | P43166 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6179423 | 0.85 | GAA (0.49) | RXFP1CA12CA1CA2CA7 | |
| SCHEMBL10712967 | 0.83 | CA12 (0.45) | RXFP1CA12CA1CA2CA7 | |
| SCHEMBL3310733 | 0.82 | KDR (0.43) | CA12CA1CA2CA7CA9 | |
| SCHEMBL10627374 | 0.82 | CA12 (0.59) | CA12CA1CA2CA7CA9 | |
| SCHEMBL12326380 | 0.81 | ALDH1A1 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL28532275 | 0.81 | KDR (0.39) | RXFP1SMN1; SMN2MAPTALDH1A1ALOX15 | |
| SCHEMBL4867955 | 0.79 | CA12 (0.47) | CA12CA1CA2CA7CA9 | |
| SCHEMBL17210813 | 0.79 | KDM4E (0.44) | RXFP1CA9CYP3A4MAPTALDH1A1 | |
| SCHEMBL27694753 | 0.79 | CA12 (0.50) | CA12CA1CA2CA7CA9 | |
| SCHEMBL2312711 | 0.79 | MAPT (0.54) | SMN1; SMN2TDP1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008147697-A1 | BENZIMIDAZOLONE CHYMASE INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2008-12-04 | — | — | WO | disclosed |