Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | SUV39H2 | Q9H5I1 | 4/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4573910 | 1.00 | HDAC1 (0.50) | HDAC1MAP4K4SUV39H2GPR119RET | |
| SCHEMBL16334066 | 0.87 | HDAC1 (0.49) | HDAC1MAP4K4SUV39H2GPR119GRM1 | |
| SCHEMBL4573147 | 0.86 | GRM1 (0.39) | HDAC1SUV39H2GRM1PIK3CD | |
| SCHEMBL8107805 | 0.86 | HDAC1 (0.49) | HDAC1MAP4K4SUV39H2GPR119RET | |
| SCHEMBL17310207 | 0.82 | RET (0.53) | MAP4K4SUV39H2GPR119RET | |
| SCHEMBL31105042 | 0.81 | MAP4K4 (0.54) | HDAC1MAP4K4SUV39H2GPR119GRM1 | |
| SCHEMBL21460229 | 0.81 | MAP4K4 (0.54) | HDAC1MAP4K4SUV39H2GPR119GRM1 | |
| SCHEMBL21460227 | 0.81 | MAP4K4 (0.54) | HDAC1MAP4K4SUV39H2GPR119GRM1 | |
| SCHEMBL29498327 | 0.81 | MAP4K4 (0.54) | HDAC1MAP4K4SUV39H2GPR119GRM1 | |
| SCHEMBL30427123 | 0.81 | MAP4K4 (0.54) | HDAC1MAP4K4SUV39H2GPR119GRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |