Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM1 | Q13255 | 7/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.39 |
| ▸ | PRKG1 | Q13976 | 2/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | TACR3 | P29371 | 2/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | CTSS | P25774 | 1/20 | 0.36 |
| ▸ | CTSK | P43235 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117495 | 0.86 | HDAC1 (0.50) | GRM1SUV39H2PIK3CDHDAC1 | |
| SCHEMBL4573910 | 0.86 | HDAC1 (0.50) | GRM1SUV39H2PIK3CDHDAC1 | |
| SCHEMBL4573353 | 0.84 | CTSB (0.42) | GRM1ROCK2PRKG1CTSBCTSS | |
| SCHEMBL17310021 | 0.80 | KDM4E (0.43) | PARP1 | |
| SCHEMBL25187577 | 0.78 | GRM1 (0.45) | GRM1PIK3CDHDAC1 | |
| SCHEMBL4573090 | 0.77 | CHRM4 (0.45) | GRM1PIK3CD | |
| SCHEMBL20210778 | 0.77 | SUV39H2 (0.36) | GRM1SUV39H2RBP4 | |
| SCHEMBL17310137 | 0.77 | SUV39H2 (0.36) | GRM1SUV39H2RBP4 | |
| SCHEMBL4574023 | 0.77 | PIK3CD (0.43) | GRM1ROCK2PRKG1PIK3CDCTSB | |
| SCHEMBL21808506 | 0.77 | GRM1 (0.50) | GRM1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |