Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 2/20 | 0.54 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.54 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.41 |
| ▸ | PPIB | P23284 | 1/20 | 0.40 |
| ▸ | PPIA | P62937 | 1/20 | 0.40 |
| ▸ | PPID | Q08752 | 1/20 | 0.40 |
| ▸ | PPIG | Q13427 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3862461 | 0.84 | CYP4F2 (0.61) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL6982335 | 0.82 | CYP4F2 (0.59) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL12251331 | 0.82 | CYP4F2 (0.52) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL490553 | 0.82 | CYP4F2 (0.55) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL6985238 | 0.81 | CYP4F2 (0.58) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL6982334 | 0.81 | CYP4F2 (0.58) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL7158157 | 0.81 | CYP4F2 (0.58) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL9713994 | 0.80 | CYP4F2 (0.56) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| SCHEMBL12723403 | 0.80 | CYP4F2 (0.56) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A | |
| Hydrochloric Acid SCHEMBL6982842 | 0.80 | CYP4F2 (0.56) | CYP4F2CYP4A11CYP4Z1PDE3BPDE3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763524-B1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO CO (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-6040339-A | TREATMENT AND PROPHYLAXIS OF HYPERCHOLESTEREMIA OR ARTERIOSCLEROSIS IN A MAMMAL | SANKYO COMPANY, LIMITED (JP) | 2000-03-21 | — | — | US | disclosed |
| US-5880147-A | Amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prohylactic use | SANKYO COMPANY, LIMITED (JP) | 1999-03-09 | — | — | US | disclosed |
| EP-0763524-A1 | Urea and amide derivatives having ACAT inhibitory activity, their preparation and their therapeutic and prophylactic use | SANKYO COMPANY LIMITED (JP) | 1997-03-19 | — | — | EP | disclosed |