Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTAFR | P25105 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | GALR3 | O60755 | 2/20 | 0.47 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TNF | P01375 | 1/20 | 0.47 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.47 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8129576 | 1.00 | PTAFR (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8134167 | 0.94 | PTAFR (0.56) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8126891 | 0.93 | PTAFR (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8131799 | 0.91 | PTAFR (0.50) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8127846 | 0.90 | HDAC1 (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8134050 | 0.90 | HDAC1 (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8124045 | 0.90 | HDAC1 (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8129749 | 0.89 | AGTR2 (0.56) | PTAFRHDAC1HDAC6AGTR1AGTR2 | |
| SCHEMBL8134171 | 0.89 | TNF (0.53) | PTAFRHDAC1HDAC6GALR3NR2F2 | |
| SCHEMBL8135468 | 0.88 | PTAFR (0.69) | PTAFRS1PR1TBXAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | claimed |
| WO-1992003423-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | claimed |
| EP-0543858-B1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARM (GB) | 2000-12-20 | — | — | EP | disclosed |
| US-5451676-A | Treatment of hypotension and bronchoconstriction | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1995-09-19 | — | — | US | disclosed |
| US-5274094-A | Diseases or conditions mediated by platelet-activating factor; cyclization of a diamino compound with a carboxylic acid | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-12-28 | — | — | US | disclosed |
| EP-0543858-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIOTECH PHARMACEUTICALS LIMITED (GB) | 1993-06-02 | — | — | EP | disclosed |
| US-5200412-A | Antiinflammatory agents and antiallergens | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1993-04-06 | — | — | US | disclosed |
| WO-1992003423-A1 | BENZIMIDAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND APPLICATION | BRITISH BIO-TECHNOLOGY LIMITED (GB) | 1992-03-05 | — | — | WO | disclosed |